Search results for "Sugar derivatives"

showing 3 items of 3 documents

Synthesis, chemical characterization and preliminary in vitro antitumor activity evaluation of new ruthenium(II) complexes with sugar derivatives

2011

Abstract Three new complexes of Ru(II), namely [RuCl 2 (Glun-N,O) 2 ]Na 2 ( I ; Glun = glucosaminate), [RuCl 2 (1-Tglu)(EtOH) 2 ]Na ( II ; 1-Tglu = 1-thio-β- d -glucose) and [Ru 2 (EtOH) 6 (AL)Cl 4 ] ( III ; AL = 6′-aminolactose) were prepared from the same Ru(II) precursor, [RuCl 2 (DMSO) 4 ] (DMSO = dimethyl sulfoxide). The characterization of the complexes was carried out by elemental analysis, FT-IR, ES-MS, NMR, EXAFS and DFT calculations. The effectiveness of the complexes on metastatic melanoma A 375 was investigated. The results show that complex II is the most active species.

Antitumor activityCarbohydrates Anti-cancer Melanoma A375Extended X-ray absorption fine structureMetastatic melanomaStereochemistrychemistry.chemical_elementSulfoxideMedicinal chemistryIn vitroRutheniumInorganic ChemistrySugar derivativeschemistry.chemical_compoundchemistryElemental analysisMaterials ChemistryPhysical and Theoretical Chemistry
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11B-MAS NMR approach to the boron adsorption mechanism on a glucose-functionalised mesoporous silica matrix

2018

[EN] Boron chemistry has raised much interest because, despite the difference between necessities and toxicity being very narrow, it is still widely used in industrial processes. In a previous work we reported an adsorbent for boron extraction from water by the functionalisation of a UVM-7 mesoporous silica matrix with gluconamide moieties. The ability of this material to adsorb boron is based on its well-known affinity for coordinating the cis-diols present in attached saccharide. Although much research on the formation of boron esters with sugars and sugar derivatives in solution has been done, very few reports have dealt with the adsorption mechanism of boron onto functionalised material…

Materials scienceBoron adsorption modellingSolid-statechemistry.chemical_element02 engineering and technology010402 general chemistry01 natural sciencesIsothermal processMatrix (chemical analysis)AdsorptionQUIMICA ORGANICAGeneral Materials ScienceBoronExtraction (chemistry)QUIMICA INORGANICAGeneral Chemistry[CHIM.MATE]Chemical Sciences/Material chemistryB-11 MAS NMRMesoporous silica021001 nanoscience & nanotechnologyCondensed Matter PhysicsGluconamide-functionalised porous materials0104 chemical sciencesSugar derivatives[CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistryChemical engineeringchemistryMechanics of Materials0210 nano-technology
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Structure of a polysaccharide from the lipopolysaccharide of Vibrio vulnificus clinical isolate YJ016 containing 2-acetimidoylamino-2-deoxy-L-galactu…

2009

Abstract A polysaccharide isolated after mild acid degradation of the lipopolysaccharide of Vibrio vulnificus clinical isolate YJ016 was found to contain l -Fuc, d -GlcpNAc, 2,4-diacetamido-2,4,6-trideoxy- d -glucose (di-N-acetylbacillosamine, d -QuiNAc4NAc), and 2-acetimidoylamino-2-deoxy- l -galacturonic acid ( l -GalNAmA). The last sugar derivative was confirmed by correlations for nitrogen-linked protons in 2D TOCSY and ROESY spectra measured in a H2O–D2O mixture. The following structure of the polysaccharide was established by 1H and 13C NMR spectroscopy, including 2D ROESY and 1H,13C HMBC experiments: Download : Download full-size image where the degree of 6-O-acetylation of the later…

chemistry.chemical_classificationLipopolysaccharidesMagnetic Resonance SpectroscopybiologyLipopolysaccharideChemistryStereochemistryOrganic ChemistryMolecular Sequence DataPolysaccharides BacterialGeneral MedicineVibrio vulnificusbiology.organism_classificationPolysaccharideBiochemistryAnalytical ChemistrySugar derivativesResidue (chemistry)chemistry.chemical_compound13c nmr spectroscopyBiochemistryCarbohydrate SequenceGalacturonic acidVibrio vulnificusCarbohydrate research
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